The Challenge

The overall aim of the iToBoS project is to build a new diagnostic tool for the early detection of melanoma, exploiting all the available information of the patient. This holistic assessment tool should understand the specific characteristics of every patient in order to enable a personalised, early detection of melanoma.

The developments within the project will lead to a precision diagnostic system that will incorporate classical demographic data (age, sex), clinical phenotype (anatomical location of every lesion and skin phototype), genotype (mutations in hereditary melanoma genes and genetic variations in melanoma susceptibility genes) and an imaging phenotype (including number and size of naevi, degree and area of photo-damaged skin, as well as clinical dermoscopic image characteristics of the lesions, acquired by the total-body high-resolution scanner). The combination of all this personalised information will result in an accurate, detailed and structured assessment of the pigmented skin lesions of the patient.

Concept of the skin scanner component of the integrative diagnostic platform of iToBoS comprising five high-resolution imaging modules: